Title: Negative Feedback and Robustness Trade-offs in Systems Biology (1 hour)
Abstract: A standard result from Metabolic Control Analysis states that when addressing the effect of perturbations of enzyme activity on a metabolic pathway, a conservation of sensitivity holds: the sum over the relative sensitivity at each enzyme is equal to one.
This result mirrors conservation statements that appear as performance constraints in control engineering. In fact, this Summation Theorem shares a common foundation with the familair constraint that "sensitivity plus complementary sensitivity sum to one" (S+T=1). We will explore this common foundation in the context of biochemical and genetic networks.